reSET-O® is a 12-week prescription digital therapeutic for patients with opioid use disorder who are in outpatient treatment. It provides cognitive behavioral therapy, as an adjunct to outpatient treatment that includes transmucosal buprenorphine and contingency management, for patients who are currently under the supervision of a clinician. reSET-O® is the only FDA-authorized prescription digital therapeutic that’s clinically proven to help people with opioid use disorder stay in treatment longer (1,2). Get buprenorphine reminders. Set up daily reminders to take your medication. Get therapy on demand. Interactive Cognitive Behavioral Therapy lessons help you learn new skills you can use in everyday situations to support your recovery journey (2). Strengthen coping strategies. Questions at the end of each lesson help you remember important ideas and practice skills to stay in treatment (2). Earn rewards. Use an evidence-based rewards system designed to support your recovery and treatment (2). Track your cravings and triggers. Record substance use, cravings, and triggers with just a tap, so you and your therapist or doctor can better understand how you’re doing (2). If you’ve been in an outpatient treatment program before for opioid use disorder, you know that recovery can be a challenging, ongoing process. Especially in between therapy sessions, when you may not be able to access a counselor or doctor but still need support. reSET-O is a Prescription Digital Therapeutic—a new type of therapy prescribed by doctors designed to help with treatment. It works in conjunction with buprenorphine medication assisted therapy, and lets you continue the work you’re doing in recovery on your smartphone or tablet, so you can build new skills and get support—anytime, anywhere. Important Safety Information Warnings/precautions: Do not use reSET-O to communicate any emergency, urgent or critical information. reSET-O does not include features that can send alerts or warnings to your clinician. If you have feelings or thoughts of harming yourself or others, please dial 911 or go to the nearest emergency room. reSET-O is intended for patients whose primary language is English or Spanish, who have access to a compatible tablet or smartphone and are familiar with the use of smartphone applications (apps). You should be able to upload data periodically, i.e. have internet/wireless connection access. reSET-O requires you to enter a user name and password prior to use. Please do not share your user name and password with others. reSET-O may contain and transmit protected health information and/or personally identifiable information. reSET-O is not intended to be used as stand-alone therapy for Opioid Use Disorder (OUD) and does not replace care by your provider. reSET-O is not a substitute for your medications. You should continue to take your medications as directed by your provider. The long-term benefit of reSET-O has not been evaluated in studies lasting beyond 12 weeks (84 days) in the OUD population. The ability of reSET-O to prevent potential relapse after therapy discontinuation has not been studied. Please see the Patient Brief Summary Instructions for reSET-O: https://bit.ly/2Bs7kB8 1. FDA clears mobile medical app to help those with opioid use disorder stay in recovery programs. News release. Silver Spring, MD: US Food and Drug Administration. December 10, 2018. Accessed May 18, 2020. https://www.fda.gov/news-events/press-announcements/fda-clears-mobile-medical-app-help-those-opioid-use-disorder-stay-recovery-programs 2. reSET-O Patient directions for use. Pear Therapeutics, Inc. 2020.

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